Of the 1,896 women with normal cytology and HPV mRNA test (intervention group), 49 women (2.6%) had a positive test. The risks of CIN3+ among women with either a positive or negative HPV mRNA test were 28.6% (14/49) and 0.8% (14/1847). None of the women in the intervention group developed cervical cancer during follow-up.
HPV DNA testing. A large amount of published data over recent decades on HPV DNA testing by means of pooled-based or type-specific methods has definitely demonstrated that persistent positivity of viral infection is considered a prognostic index of persistent/recurrent disease in patients treated for CIN2–3/ AIS.
Papillomaviruses are small, non-enveloped, epitheliotropic, double-stranded DNA viruses that infect mucosal and cutaneous epithelia in a wide variety of higher vertebrates in a species-specific manner and induce cellular proliferation. Only bovine papillomaviruses (BPVs) 1 and 2 are known to infect mesenchymal tissues and to show cross-species transmission. More than 100 types of human
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    • hpv dna test negative means